Testing of Antioxidants against Experimental Caries in Rats

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Abstract
A number of antioxidants were tested for their effect on sulcal caries in rats. Propyl gallate and l,2-dihydro-6-ethoxy-2,2,4-trimethyl-quinoline inhibited caries by approximately 50% when incorporated in the diet at 0.5% level. The other antioxidants, including a-tocopherol, ascorbic acid, isoascorbic acid, butylated hydroxyanisole, ethyl hydro-caffeate, rutin, hesperidin, butylated hydroxytoluene, and nordihydro-guaiaretic acid, did not inhibit caries. In fact, the caries scores of some groups were slightly increased. In the case of hesperidin, the increase was statistically significant. These compounds were generally not inhibitory to the growth of selected test bacteria under the conditions used for testing. Exceptions were propyl gallate, l,2-dihydro-6-ethoxy-2,2,4-trimethylquinoline, ethyl hydrocaffeate, and nordihydroquaiaretic acid.