The Fate of 2,6-Dimethoxy[U-14C]phenol in the Rat
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 4 (5) , 285-289
- https://doi.org/10.3109/00498257409052056
Abstract
1. The metabolic fate of 2,6-dimethoxy[U-14C]phenol, administered intravenously to rats at three dose levels (10–30 mg/kg body wt.), was investigated. 2. The majority of injected radioactivity appeared in urine but significant amounts were eliminated via the bile (16.3–35.4%). 3. The urinary radioactivity was associated with two metabolites identified as 2,6-dimethoxy[U-14C]phenylglucuronide and 2,6-dimethoxy[U-14C]phenylsulphate. The glucuronide conjugate predominated in the female rat while approximately equal amounts of the conjugates were produced by the male. 4. The biliary metabolite was identified as 2,6-dimethoxy[U-14C]phenyl-glucuronide.Keywords
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