Increase in Antibiotic Resistance among Isolates of Salmonella in the United States, 1967-1975

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Abstract
To study temporal changes in the antibiotic resistance of Salmonella in the United States, a study design similar to that of a 1967study was used to determine the antibiotic sensitivity of 754 human nontyphoid Salmonella isolates sent to the Center for Disease Control, Atlanta, Georgia, in 1975. The frequency of resistance to one or more of the same nine antibiotics used in both studies increased significantly during the eight years in Salmonella typhimurium (40%–59%; P = 0.004), other serotypes (14%–23%; P = 0.001), and all serotypes combined (21%–31 %; PP = 0.022), sulfonamides (P< 0.001), ampicillin (P < 0.001), and kanamycin (P < 0.001). No chloramphenicol-resistant isolates were found in the 1967study, whereas six isolates (0.8%) were resistant in 1975. The frequency of strains resistant to six or more antibiotics increased greatly (0.8%–5.0%; P < 0.001). These data document a continuing increase in antimicrobial resistance among Salmonella isolates.

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