Synthesis of aryltetralin and dibenzylbutyrolactone lignans: (±)-lintetralin, (±)-phyltetralin, and (±)-kusunokinin

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Abstract
Application of a general synthetic pathway for aryltetralin and dibenzylbutyrolactone lignans, starting from the lithium enolate of 3-(3,4-dimethoxybenzyl)butyrolactone (1) led to syntheses of (±)-lintetralin (4), (±)-phyltetralin (5), (±)-isogalcatin (12), and (±)-kusunokinin (13).