POST‐ANTIBIOTIC EFFECT AND KILLING ACTIVITY OF CIPROFLOXACIN AGAINST STAPHYLOCOCCUS AUREUS
- 1 September 1987
- journal article
- research article
- Published by Wiley in Acta Pathologica Microbiologica Scandinavica Series B: Microbiology
- Vol. 95B (1-6) , 199-202
- https://doi.org/10.1111/j.1699-0463.1987.tb03112.x
Abstract
The effect of ciprofloxacin on eight strains of Staphylococcus aureus were examined. A post-antibiotic effect was observed in all strains, varying between 1.65 and 2.75 hours, with concentration of ciprofloxacin at 5 times the Minimum Inhibitory Concentration (MIC) exposed for 1 hours. Killing-kinetic studies at 5 times the MIC showed a decrease in the numbers of organisms by approximately 2.1 log10 after 6 hours, independent of the growth phase. A significantly increased susceptibility of S. aureus to the bactericidal activity of ciprofloxacin during recovery from the PAE-phase was demonstrated.Keywords
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