Molecular pathogenesis of iron overload
Open Access
- 1 August 2002
- Vol. 51 (2) , 290-295
- https://doi.org/10.1136/gut.51.2.290
Abstract
Our current understanding of iron absorption under normal conditions is presented, together with an overview of the clinical disorders of iron overload and the molecular processes that contribute to increased iron deposition in iron overload. Recently, a number of new genes involved in iron metabolism have been identified which is allowing the molecular mechanisms of iron absorption to be elucidated.Keywords
This publication has 83 references indexed in Scilit:
- A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron OverloadJournal of Biological Chemistry, 2001
- Comparison of the Interactions of Transferrin Receptor and Transferrin Receptor 2 with Transferrin and the Hereditary Hemochromatosis Protein HFEJournal of Biological Chemistry, 2000
- Hereditary Hemochromatosis in Adults without Pathogenic Mutations in the Hemochromatosis GeneNew England Journal of Medicine, 1999
- A Population-Based Study of the Clinical Expression of the Hemochromatosis GeneNew England Journal of Medicine, 1999
- Juvenile Hemochromatosis Locus Maps to Chromosome 1qAmerican Journal of Human Genetics, 1999
- Inhibition of uptake of transferrin-bound iron by human hepatoma cells by nontransferrin-bound ironHepatology, 1997
- Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter geneNature Genetics, 1997
- Transferrin receptor-independent uptake of differic transferrin by human hepatoma cells with antisense inhibition of receptor expressionHepatology, 1996
- Acetalde hyde‐Induced Stimulation of Collagen Synthesis and Gene Expression Is Dependent on Conditions of Cell Culture: Studies with Rat Lipocytes and FibroblastsAlcohol, Clinical and Experimental Research, 1994
- Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood DonorsNew England Journal of Medicine, 1988