Identification of a toxic impurity in commercial diphenylamine
- 1 January 1981
- journal article
- research article
- Published by Taylor & Francis in Journal of Environmental Science and Health, Part B
- Vol. 16 (2) , 125-130
- https://doi.org/10.1080/03601238109372245
Abstract
The impurity in commercial diphenylamine which induces poly‐cystic kidney disease in rats has been identified as N,N,N'‐tri‐phenyl‐p‐phenylenediamine. The structure of the compound was confirmed by mass and proton magnetic resonance spectrometry and by comparison with a synthetic standard prepared by the Ullman coupling of iodobenzene and p‐phenylenediamine or N,N‐diphenyl‐p‐phenylene‐diamine. Laboratory studies with highly purified diphenylamine indicated that N,N,N'‐triphenyl‐p‐phenylenediamine can be formed by heating diphenylamine.Keywords
This publication has 2 references indexed in Scilit:
- EVOLUTION OF COLLECTING TUBULAR LESION IN DIPHENYLAMINE-INDUCED RENAL-DISEASE1978
- Identification of toxic impurities in commercial DiphenylamineBulletin of Environmental Contamination and Toxicology, 1977