Exercise induced mobilisation of the marginated granulocyte pool in the investigation of ethnic neutropenia

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Abstract
This study was designed to determine whether ethnic neutropenia is caused by an increased proportion of neutrophils being present in the marginated granulocyte pool. Thirty two healthy volunteers, half of whom were African or Afro-Caribbean and half of whom were white, exercised vigorously for 10 minutes on a step machine to mobilise granulocytes from the marginated granulocyte pool into the circulating granulocyte pool. The amount of work performed and the pulse rate response of the two ethnic groups were compared to determine whether the exercise carried out was comparable. A full blood count and an automated differential count were performed before and after the exercise. The haemoglobin concentration, platelet count, and absolute counts of total leucocytes and leucocyte subsets before and after exercise were compared in each individual and the values in the two ethnic groups both before and after exercise were compared. The absolute increase in neutrophils in the two ethnic groups was compared. The African/Afro-Caribbean group was found to have a reduced rather than enhanced ability to mobilise neutrophils from the marginated granulocyte pool. Therefore, increased margination of neutrophils is unlikely to be the cause of ethnic neutropenia.