Genetic localization of Bethlem myopathy

Abstract
In spite of slowly ongoing deterioration of muscle power, ability to work is preserved until old age. [2] Many patients remain ambulant, often with the help of a cane, whereas others become wheelchair-dependent for outdoor transportation (manuscript in preparation). There is no cardiac involvement [2,5] and life expectancy is unaffected. [1] Ancillary investigations such as electrophysiologic studies and muscle biopsy indicate a myopathic origin of the disease. [2]