Macroprolactin and the Roche Elecsys Prolactin Assay: Characteristics of the Reaction and Detection by Precipitation with Polyethylene Glycol
Open Access
- 1 December 2000
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 46 (12) , 1993-1995
- https://doi.org/10.1093/clinchem/46.12.1993
Abstract
Prolactin occasionally is present in serum in a macromolecular complex. The most common form is macroprolactin, an antibody-antigen complex of prolactin (PRL) and immunoglobulin G with a molecular mass of 150–170 kDa ( 1)( 2)( 3)( 4). The PRL component remains reactive (to various degrees) in immunoassays for PRL ( 5)( 6)( 7), and macroprolactin is cleared more slowly than PRL from the circulation, leading to apparent hyperprolactinemia ( 8).Keywords
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