Rank-Order of Potencies for Inhibition of the Secretion of Aβ40 and Aβ42 Suggests That Both Are Generated by a Single γ-Secretase
Open Access
- 1 July 1999
- journal article
- Published by Elsevier
- Vol. 274 (29) , 20499-20504
- https://doi.org/10.1074/jbc.274.29.20499
Abstract
No abstract availableKeywords
This publication has 38 references indexed in Scilit:
- Amyloid β-Protein and the Genetics of Alzheimer's DiseaseJournal of Biological Chemistry, 1996
- Amyloid β protein (Aβ) deposition in chromosome 14–linked Alzheimer's disease: Predominance of Aβ42(43)Annals of Neurology, 1996
- Therapeutic Approaches Related to Amyloid-.beta. Peptide and Alzheimer's DiseaseJournal of Medicinal Chemistry, 1995
- Evidence that Aβ42 is the real culprit in alzheimer's diseaseAnnals of Neurology, 1995
- Elevated Aβ levels in Alzheimer's disease brain are associated with selective accumulation of Aβ42 in parenchymal amyloid plaques and both Aβ40 and Aβ42 in cerebrovascular depositsAmyloid, 1995
- Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatumBrain Research, 1994
- Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron, 1994
- The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's diseaseBiochemistry, 1993
- Release of Excess Amyloid β Protein from a Mutant Amyloid β Protein PrecursorScience, 1993
- Isolation and quantification of soluble Alzheimer's β-peptide from biological fluidsNature, 1992