Metabolism of glycyrrhizin by human intestinal flora. II. Isolation and characterization of human intestinal bacteria capable of metabolizing glycyrrhizin and related compounds.

Publisher Website
Google Scholar
Abstract
In a survey of intestinal bacteria capable of metabolizing glycyrrhizin (GL), Ruminococcus sp. PO1-3 and Clostridium innocuum ES24-06 were isolated from human feces. The former strain had the ability to hydrolyze GL to glycyrrhetic acid (GA) and to reduce 3-dehydroglycyrrhetic acid (DGA) to GA while the latter strain had the ability to reduce DGA to 3-epi-glycyrrhetic acid (EGA). A mixture of the 2 strains could not only reduce DGA to GA and EGA, but also epimerize GA to EGA and vice versa, possibly through a 3-dehydro intermediate.

This publication has 3 references indexed in Scilit: