Endogenous Superantigens Shape Response to Exogenous Superantigens
- 1 September 2005
- journal article
- Published by American Society for Microbiology in Clinical and Vaccine Immunology
- Vol. 12 (9) , 1119-22
- https://doi.org/10.1128/cdli.12.9.1119-1122.2005
Abstract
Endogenous superantigen-mediated thymic negative selection resulted in a paucity of mature T cells bearing T-cell receptor (TCR) Vβ8 in the periphery. Consequently, the magnitude of immune response to exogenous superantigen staphylococcal enterotoxin B, which activates TCR Vβ8 + T cells, was significantly reduced and conferred protection from superantigen-induced mortality.Keywords
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