EFFECTS OF ADRENALINE AND NORADRENALINE ON GLUCOSE‐INDUCED ELECTRICAL ACTIVITY OF MOUSE PANCREATIC β CELL
- 7 April 1983
- journal article
- Published by Wiley in Quarterly Journal of Experimental Physiology
- Vol. 68 (2) , 247-258
- https://doi.org/10.1113/expphysiol.1983.sp002716
Abstract
The effects of adrenaline and noradrenaline on membrane potential and glucose‐induced electrical activity were studied in micro‐dissected mouse Islets of Langerhans. Both catecholamines induced hyperpolarization and blocked electrical activity in the presence of 11·1 mM glucose. Phentolamine, but not propranalol, blocked these effects, indicating predominantly α receptor action. Quinine, but not tetraethylammonium ions, antagonized the inhibitory effects of the catecholamines. The data are consistent with the hypothesis that α receptor activation induces a transient increase in intracellular Ca2+ concentration which in turn leads to an increase in K+ permeability.Keywords
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