Diversity of microRNAs in human and chimpanzee brain
Top Cited Papers
- 29 October 2006
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 38 (12) , 1375-1377
- https://doi.org/10.1038/ng1914
Abstract
We used massively parallel sequencing to compare the microRNA (miRNA) content of human and chimpanzee brains, and we identified 447 new miRNA genes. Many of the new miRNAs are not conserved beyond primates, indicating their recent origin, and some miRNAs seem species specific, whereas others are expanded in one species through duplication events. These data suggest that evolution of miRNAs is an ongoing process and that along with ancient, highly conserved miRNAs, there are a number of emerging miRNAs.Keywords
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