Bovine Collagen Implant: Histologic Chronology in Pig Dermis
- 1 November 1983
- journal article
- Published by Wiley in The Journal of Dermatologic Surgery and Oncology
- Vol. 9 (11) , 889-895
- https://doi.org/10.1111/j.1524-4725.1983.tb01036.x
Abstract
The histologic fate of an injectable form of type I bovine dermal collagen (Zyderm Collagen Implant, ZCI) in the pig dermis and subcutaneous tissue has been studied. Biopsies were taken sequentially and analyzed by hematoxylin and eosin (H&E) and Weigert's stain, by birefringence, by direct immunofluorescence (using a highly specific rabbit anti‐Zyderm antibody), and by electron microscopy. The implant material was found to stimulate a host response resulting in implant degradation and replacement by newly generated host collagen.Keywords
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