Sphincteric Mechanism of the Main Pancreatic Duct in the Dog

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Abstract
This study describes an in vitro experimental model of the sphincter at the lower end of the main pancreatic duct in the dog. This model, employing a drop counter to measure the drop rate, monitors the perfusion rate of Tyrode through the sphincter. Acetylcholine (ACh), employed to establish the sensitivity and viability of the isolated sphincter, produced a contraction of the sphincter which was concentration-response related. Saline, as a control, atropine and hexamethonium did not affect the drop rate. Atropine (20 μg) partially abolished the contraction produced by 50 μg of ACh; hexamethonium (50 μg) did not have an effect. Caerulein 50 μg produced a relaxation of the sphincter; adrenaline 50 μg a contraction. Both sympathetic and parasympathetic mechanisms seem to play a role in the regulation of sphincteric activity of the main pancreatic duct in dogs.