Radical Cyclization of (Bromomethyl)dimethylsilyl Propargyl Ethers; VI. Serial Radical Cyclizations Leading to a Stereoselective Synthesis of Functionalized Diquinane Framework from an Acyclic Substrate1
- 1 January 1990
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1990 (06) , 320-321
- https://doi.org/10.1055/s-1990-21076
Abstract
Radical cyclization of 4-[(bromomethyl)dimethyl-siloxy)-2-methyl-1-undecene-5-yne in the presence of acrylonitrile leads stereoselectively by a radical reaction cascade to the diquinane system. This one-pot reaction allows the consecutive formation of four carbon-carbon bonds, with two contiguous quaternary centers and controls the stereoselective construction of four stereogenic centers.Keywords
This publication has 0 references indexed in Scilit: