COMPARISON OF RABBIT ANTIMOUSE THYMUS SERA PRODUCED AFTER DIFFERENT NUMBERS OF INJECTIONS OF LYMPHOID CELLS
- 1 September 1969
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 8 (3) , 249-257
- https://doi.org/10.1097/00007890-196909000-00006
Abstract
SUMMARY: The relative immunosuppressive properties of rabbit antimouse thymus sera produced following the injection of viable murine thymie cells two to eight times were compared in a murine skin allograft system. The immunosuppressive effects of the sera weakened markedly as the number of injections of thymie cells increased. No correlation existed between the eytotoxicity in vitro of any serum for murino lymphocytes and its immunosuppressive activity in vivo. The lymphocytotoxicity lost species specificity as (he number of injections of thymie cells increased. Rabbit antimouse thymus sera raised in response to i.p. injections of thymie tissue did not produce lymphopenia acutely in vivo in mice although they were immunosuppressive. However, sera raised after two to five i.v. injections of thymie cells did induce lymphopenia, while those obtained after seven or eight injections did not, a change that paralleled their loss of immunosuppressive activity.Keywords
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