HYPOPROTEINEMIA in newborn and premature infants has been noted by several investigators.1These studies, however, (Footnote continued on next page) have not correlated exactly the weight at birth and the degree of hypoproteinemia, nor have they demonstrated serially the levels of the blood proteins observed over a period of time in the same infants. Recently, when the products of fractionation of human plasma became available for study,2it seemed that there might be possible advantage in the use of concentrated normal human serum albumin for premature infants, particularly if repeated determinations for such infants demonstrated little or no increase in the plasma proteins. In order to define the problem more clearly, we decided to recheck the values for plasma proteins in both normal full term and normal premature infants, to follow carefully over a period of time the protein values observed for a number of small premature infants