Diheteropeptin, a New Substance with TGF-.BETA.-like Activity, Produced by a Fungus, Diheterospora chlamydosporia. I. Production, Isolation and Biological Activities.
- 1 January 2000
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 53 (8) , 788-792
- https://doi.org/10.7164/antibiotics.53.788
Abstract
A new metabolite, diheteropeptin, was found in the culture broth of Diheterospora chlamydosporia Q58044 by screening for TGF-β-like active substances. Diheteropeptin was extracted from the culture supernatant and purified by a series of chromatographies such as silica gel, gel filtration and HPLC. Diheteropeptin exhibited cytostatic activity in MvlLu cells with an IC50 value of 20.3 μM and inhibited histone deacetylase.Keywords
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