Polyclonal Origin of Colonic Adenomas in an XO/XY Patient with FAP
- 24 May 1996
- journal article
- case report
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 272 (5265) , 1187-1190
- https://doi.org/10.1126/science.272.5265.1187
Abstract
It is widely accepted that tumors are monoclonal in origin, arising from a mutation or series of mutations in a single cell and its descendants. The clonal origin of colonic adenomas and uninvolved intestinal mucosa from an XO/XY mosaic individual with familial adenomatous polyposis (FAP) was examined directly by in situ hybridization with Y chromosome probes. In this patient, the crypts of the small and large intestine were clonal, but at least 76 percent of the microadenomas were polyclonal in origin.Keywords
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