Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable forin vivo testing of ether lipids and their derivatives
- 1 February 1992
- journal article
- Published by Springer Nature in Breast Cancer Research and Treatment
- Vol. 23 (1) , 87-95
- https://doi.org/10.1007/bf01831480
Abstract
Summary The human mammary carcinomas MT-1 and MT-3 originate from surgical material and were transplanted in nude mice. Both tumors have been classified as estradiol- and progesterone receptor-negative. Therapeutic doses of hormones and anti-hormones remained without growth inhibitory effect. MT-1 and MT-3 proved to be sensitive to conventional cytostatic drugs used for treatment of mammary carcinomas; striking is their sensitivity to ether lipids. Therefore, they are considered suitable tumor models for this class of substances.Keywords
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