Effect of Chronic Ethanol Feeding on Rat Liver Phospholipid

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Abstract
Determinations of liver phospholipid concentration and composition were made in experiments to investigate the effect of chronic ethanol ingestion on liver phospholipid metabolism in the rat. Each ethanol-fed animal was grouped with a control animal pair-fed the basal diet plus sucrose and a control animal fed the basal diet ad libitum. Both male and female animals fed ethanol developed increased concentrations of liver phospholipid; the increment in the males was greater than that in the females. Quantitative two-dimensional thin-layer chromatography of the phospholipid fractions showed an increase in lysolecithin and phosphatidyl ethanolamine in the ethanol-fed animals, whether calculated on the basis of phospholipid concentration or total liver content. The increase in lysolecithin, a membrane-lysing agent, may be relevant to alterations reported in experimental and clinical chronic alcoholism.

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