A Methods Comparison

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Abstract
Clonazepam is an antiepileptic drug for which a number of analytical procedures were presented, none of which were subjected to comparison studies. Two gas chromatographic (GC) methods involving distinct forms of detection for determining [human] plasma or serum drug levels are presented. Both methods involve simple extractions, common GC conditions and routine data reduction. Both employ nitrazepam as an internal standard, require 1 ml of sample and have a detection limit of 1 ng/ml. The 2 methods, GC-electron capture and GC-mass spectroscopy, are precise and accurate. Correlation of the 2 methods by paired sample analysis gave a regression equation of y = 0.988x - 0.14 (no. = 30, r [correlation coefficient] = 0.971, P < 0.001). We suggest that either method is a reasonable alternative for the clinical laboratory with the proper instrumentation.

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