Plasma pentobarbitone levels
- 1 October 1976
- journal article
- research article
- Published by Wiley in Anaesthesia
- Vol. 31 (8) , 1037-1042
- https://doi.org/10.1111/j.1365-2044.1976.tb11941.x
Abstract
In fit women plasma pentobarbitone was measured by gas-liquid chromatography after 100 mg given by mouth or intramuscular injection in the buttock using aqueous and organic solutions. Differences in plasma levels with the two solutions were not striking. Considerable inter-administrator difference occurred with significantly higher plasma levels when the drug was injected by a doctor using a 4 cm 21 s.w.g. needle as compared with nurses who used no specified injection technique. The oral route gave significantly higher plasma levels than nurse-given injections.Keywords
This publication has 16 references indexed in Scilit:
- Plasma diazepam levels after single dose oral and intramuscular administrationAnaesthesia, 1975
- PLASMA-DIAZEPAM LEVELS FOLLOWING INTRAMUSCULAR INJECTION BY NURSES AND DOCTORSThe Lancet, 1974
- Slow Absorption of Intramuscular ChlordiazepoxideNew England Journal of Medicine, 1974
- Inadequate serum levels after intramuscular administration of diphenylhydantoinNeurology, 1973
- Plasma diphenylhydantoin values after oral and intramuscular administration of diphenylhydantoinNeurology, 1973
- Pharmacokinetics of pentobarbital after intravenous and oral administrationJournal of Pharmacokinetics and Biopharmaceutics, 1973
- Sedative—HypnoticsAnesthesiology, 1971
- Blood levels of pentobarbital sodium, meprobamate, and tybamate in relation to clinical effectsClinical Pharmacology & Therapeutics, 1968
- Intramuscular administration of phenytoinNeurology, 1966
- Some Physico-Chemical Factors in Drug ActionJournal of Pharmacy and Pharmacology, 1957