Syntheses et Activites Biologiques de Nouvelles (E)-Alcenyl-5 Desoxy-2′ Uridines
- 1 September 1985
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 4 (4) , 447-462
- https://doi.org/10.1080/07328318508081292
Abstract
(E) 5-Alkenyl 2′-deoxyuridines were synthesized with moderate to high yields by the palladium catalyzed coupling of alkenyl-zirconium reagents with 0–3′, 5′-his (trimethylsilyl) deoxyuridine in T H F. Some of these 5-alkenyl-dUrd analogues, i.e. the 1-decenyl (5g) and 2- (1-hydroxycyclopentyl) ethenyl (5f) derivatives, inhibited murine L1210 cell growth at a concentration of about 4 μg/ml, whereas the 5-chloro-1-pentenyl (5c), 5-cyano-1-pentenyl (5d), 5-hexyn-1-enyl (5e) and 2-(1-hydroxycyclopentyl) ethenyl (5f) were inhibitory towards herpes simplex and vaccinia virus within the concentration range of 2–60 μg/ml. However, none of the newly synthesized 5-alkenyl-dUrd analogues proved selective in its antiviral action.This publication has 20 references indexed in Scilit:
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