INDUCTION OF DIFFERENTIATION OF HUMAN MYELOID CELL-LINES BY TUMOR-NECROSIS-FACTOR IN COOPERATION WITH 1-ALPHA,25-DIHYDROXYVITAMIN-D3
- 1 May 1987
- journal article
- research article
- Vol. 47 (9) , 2236-2242
Abstract
We analyzed the combined effect of tumor necrosis factor and 1.alpha.,25-dihydroxyvitamin D3 on the differentiation of human myeloid cell lines HL-60, ML3, and U937. The two compounds synergize in inducing the morphological, phenotypic, enzymatic, and functional characteristics of cells of the monocytic lineage. Immune .gamma.-interferon synergizes with each compound to induce differentiation. However, recombinant tumor necrosis factor is much more effective than recombinant .gamma.-interferon in potentiating the effect of 1.alpha.,25-dihydroxyvitamin D3 and, alone, is also more effective than recombinant .gamma.-interferon in inducing expression of the high-affinity Fc receptor on ML3 cells. The possible physiological or pathological relevance of the synergistic effect of tumor necrosis factor and 1.alpha.,25-dihydroxyvitamin D3 on monocytic differentiation is discussed.This publication has 38 references indexed in Scilit:
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