PROSTAGLANDINS AND RENIN-ANGIOTENSIN SYSTEM IN CANINE ENDOTOXEMIA

  • 1 January 1977
    • journal article
    • research article
    • Vol. 200  (3) , 614-622
Abstract
Administration of [Escherichia coli] endotoxin to dogs caused a rapid initial decline in blood pressure followed by a transient recovery preceding death. Plasma renin activity was elevated 5 min after endotoxin administration and continued to rise throughout the course of shock. Indomethacin given 60 min after endotoxin caused an elevation of blood pressure and a 50% decrease in plasma renin activity. Pretreatment with indomethacin markedly attenuated the hemodynamic changes and the rise in plasma renin activity caused by endotoxin administration. Prostaglandin (PG) E-like material was observed in renal venous blood 30 min after endotoxin administration and was abolished by inodmethacin. In addition, a non-PG substance was found in dialysate from arterial and renal venous blood within 5 min of endotoxin administration. Renal and mesenteric angiograms were taken at various stages of shock. Endotoxin administration caused a substantial increase in the diameter of intrarenal arterial branches which was temporally associated with the appearance of PGE-like material in the renal venous effluent. The mesenteric arteries were initially and transiently constricted by endotoxin and then were markedly and chronically dilated. Indomethacin simultaneously abolished renal PG and decreased renal and mesenteric arterial diameter.

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