Different Localization of Tau Protein Kinase I/Glycogen Synthase Kinase-3β from Glycogen Synthase Kinase-3α in Cerebellum Mitochondria
- 1 October 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Biochemistry
- Vol. 118 (4) , 683-685
- https://doi.org/10.1093/oxfordjournals.jbchem.a124965
Abstract
We examined the subcellular distribution of two glycogen synthase kinase-3 (GSK-3) isoforms in rat cerebellum. Results from immunoelectron microscopy and subcellular fractionation revealed that one isoform, tau protein kinase I/GSK-3β (TPKI/GSK-3β), was present in mitochondria, but GSK-3α was not. Although the two GSK-3 isoforms seem to have similar properties, the difference of subcellular localization observed here suggests that TPKI/GSK-3β fulfills some specific function in mitochondria.Keywords
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