Monitoring the response of lymphoma patients to therapy: correlation of abdominal CT findings with clinical course and histologic cell type.

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Abstract
A review was made of 365 abdominal computed tomographic (CT) examinations in 125 patients with a histologic diagnosis of lymphoma who had undergone CT before and after therapy. Clinical correlation immediately preceding the follow-up CT examination was obtained in 100 patients. In these 100 patients, 5 distinct subgroups emerged: reduction in extent of disease without changes in internal nodal characteristics; reduction in extent of diesase with change in internal nodal characteristics; no change in extent of disease but change in internodal characteristics; and disease progression. Changes in internal nodal architecture consisted of diminished attenuation or mesenteric stranding. A 91% correlation existed between the CT findings and the clinical course. Of those patients with a worsening clinical course and follow-up CT studies suggesting a stable or improved response to therapy, relapse in the majority (57%) involved the CNS. Limited abdominal CT examination is apparently satisfactory in the post-therapy follow-up of lymphoma patients.

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