Non-Organ-Specific Cytoplasmic Antibodies Detected by Immunofluorescence

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Abstract
Appearances in the immunofluorescence test produced by mitochondrial antibodies associated with primary biliary cirrhosis (‘M’ fluorescence) are compared and contrasted with those of the cardiolipin fluorescent antibodies (‘CLF’) seen in patients with active secondary syphilis. The corresponding antigens are quite distinct but are both situated in the inner membrane of the mitochondria. A further structural connection between them is suggested by the selective staining with both antibodies of mitochondria engaged in high energy work and utilizing fatty acid pathways for energy production. Two other cytoplasmic autoantibodies are described. Both are thought to be of rare occurrence and could be absorbed-out with ribosomal subfractions of rat liver homogenates while mitochondria had no effect. The pathogenic role of all these non-organ-specific reactions is still unknown but they are thought to be stimulated by contact with viruses or other microorganisms.

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