Therapy of Infections with Cefazolin

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Abstract
Patients (16) with acute urinary tract infections, 6 with acute lower respiratory tract infections and 3 with miscellaneous infections were treated with 1 g cefazolin parenterally 3 times daily. All patients, except 1 in whom therapy was discontinued, were cured. Both i.m. and i.v. administration resulted in high-peak serum levels and concentrations after 8 h were still inhibitory to relevant pathogens. The drug was well tolerated and caused, after i.m. injection, probably less pain than does cephalotin. Cefazolin is a rational choice of therapy in severe cases of acute urinary, respiratory and other infections.

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