Absence of Anatomic Arteriovenous Shunts in Paget's Disease of Bone

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Abstract
To determine whether anatomic shunting through arteriovenous (AV) anastomoses is responsible for the circulatory abnormalities associated with Paget's disease of bone, shunting of particles, 15 to 30 μ in diameter, was measured in nine patients. In addition, relative regional perfusion, radiographs and serum alkaline phosphatase were measured. Hemodynamic data were obtained in three of the patients. No AV shunting was found, despite the fact that blood flow to the involved bone was increased in every case and AV oxygen differences were decreased in some.