Cerebrospinal Fluid Vasopressin Levels

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Abstract
THE ROLE of disordered central serotonergic (5-hydroxytryptamine [5-HT]) system function has been the most prominent driving force underlying the biological study of suicidal and impulsive aggressive behavior in human subjects. Specifically, an inverse relationship between suicidal and/or impulsive aggressive behavior and a variety of 5-HT indices has been reported in human subjects.1 A reduction in central 5-HT system function is hypothesized to lead to a reduction in behavioral constraint, so that aggressive impulses are disinhibited in individuals with reduced 5-HT system function.2 Implicit in this model is a role for interacting behaviorally facilitatory mechanisms that lead to fight or flight responses to aversive stimuli.