Creatinin Excretion in Women: Clinical Significance in Obesity

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Abstract
Linear equations expressing the relationship between body wt. and creatinin excretion are derived on the basis of a study of 50 adult [female][female]. For a known level of creatinin excretion in a given case (whether obese or not) an optimal wt. of the patient may be detd. by the application of the equation for creatinin-wt. relationship established for well-proportioned [female][female]. This optimal wt. is defined as creatinin-optimal wt. In the absence of an actual laboratory detn., the creatinin excretion and creatinin-optimal wt. may be calculated through a conversion equation from the Willoughby optimal wt. estimation, based on bone measurements. Creatinin-optimal wt. is closely compatible with clinical wt. evaluations and offers a physiologic basis for the quantitative expression of the nutritional state of the adult [female][female]. Obese [female][female] generally excrete less creatinin than the well-proportioned ones and show more striking variations in the excretion levels from one individual to another at a given wt. These variations are generally in direct agreement with clinical impressions concerning the muscularity of the obese. The desirability of clinically differentiating overwt. individuals on the basis of muscle mass into the macrosomic and microsomic type is suggested to facilitate further metabolic studies in obesity.

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