Epidural Triamcinolone and Adrenal Response to Hypoglycemic Stress in Dogs

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Abstract
The effect of an epidural steroid injection (triamcinolone) on plasma cortisol levels was studied in 12 beagle dogs following an insulin-induced hypoglycemic stress. The control group (n = 6) received epidural bupivacaine only. This group consistently increased their plasma cortisol values in response to the hypoglycemic stress induced by 0.6 U of insulin/kg administered i.v. Dogs in the study group (n = 6) received epidural bupivacaine plus 2 mg/kg of triamcinolone. This group was unable to increase their plasma cortisol values in response to similar insulin-induced hypoglycemic stress for 4 wk. Return to normal function occurred 5 wk following epidural triamcinolone. The inability of the dogs to respond to hypoglycemic stress by increasing their plasma cortisol may interfere with homeostasis and decrease their tolerance to other types of stress up to 4 wk following epidural triamcinolone administration.

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