CARCINOGENIC AZO DYES .16. TUMORIGENICITY OF 3'-HYDROXYMETHYL, 3'-FORMYL, AND 3'-CARBOXY DERIVATIVES OF 4-(DIMETHYLAMINO)AZOBENZENE IN RAT-LIVER

  • 1 January 1981
    • journal article
    • research article
    • Vol. 72  (1) , 160-165
Abstract
Male Sprague-Dawley rats were fed a cube diet containing 2.51 mmol/kg of 3''-methyl-4-(dimethylamino)azobenzene (3''-Me-DAB), 3''-CH2OH-DAB, 3''-CHO-DAB or 3''-COOH-DAB (at a level equivalent to 0.06% 3''-Me-DAB in the diet) for 1-3 mo. Almost all the livers of rats given 3''-CH2OH-DAB for 2-3 mo. or 3''-Me-DAB for 3 mo. showed marked cirrhosis macroscopically. The common histological findings were cholangiofibrosis with or without markedly atypical bile ducts. One hepatocellular carcinoma was found in the liver of a rat given 3''-Me-DAB and one in the liver of a rat given 3''-CH2OH-DAB for 3 mo. 3''-CHO-DAB and 3''-COOH-DAB did not induce these changes (including neoplastic nodules) at all. 3''-CH2OH-DAB, like 3''-Me-DAB, was a hepatocarcinogen.

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