Spontaneous and Experimental Infection of Pigeons with B. Aertrycke.

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Abstract
The apparently spontaneous development of a fatal disease in undernourished pigeons is reported. It is characterized by anemia, marked myeloid hyperplasia of bone marrow, striking increase of myeloid elements of blood, and extensive infiltration of liver and kidneys with myeloid tissue. In addition, large, nodular, often necrotic masses of mononuclear phagocytic cells are frequently scattered throughout liver, spleen, kidneys, and bone marrow. B. aertrycke was regularly recovered in pure culture from blood, liver, kidney, spleen and bone marrow. The bacteria occur in the foci of mononuclear cells, not within the collections of myelocytes. The disease has been produced experimentally in normal pigeons by intraperitoneal injection of liver emulsion from naturally infected birds, intraperitoneal injection of B. aertrycke from the same source, and by oral administration of single large doses of broth cultures. Bacteria-free filtrates of broth cultures had no demonstrable effect on normal pigeons when injected or administered orally in single large doses. Frequently pathological changes occur in the tissues of apparently normal birds.

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