ANTI-NEOPLASTIC AGENTS .52. BAILEYA-MULTIRADIATA

  • 1 January 1978
    • journal article
    • research article
    • Vol. 41  (1) , 29-36
Abstract
The desert marigold B. multiradiata Harv. and Gray (Compositae) produced a series of sesquiterpenes that markedly inhibit growth of the mouse lymphocytic leukemia P388 and the corresponding in vitro cell line. Separation guided by bioassay led to the isolation of baileyin (1), fastigilins B and C (3a and 2a), radiatin (3b), pleniradin (4a) and the new pseudoguaianolide multiradiatin (2b). The most significant antitumor activity was displayed by 2a and 3b.

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