Electrolyte balance and enzyme synthesis pattern in rat salivary glands and pancreas

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Abstract
Sodium and potassium content and water/dry ratios have been determined for unstimulated and stimulated rat salivary glands and pancreas. Results are correlated with time in the ‘secretion cycle’ of increased amylase synthesis. Increased amylase synthesis by submaxillary and sublingual glands promptly follows the onset of stimulation but is delayed in parotid gland and pancreas by a dependence on gland amylase depletion. Unstimulated submaxillary and sublingual glands from fasted animals have a relatively low Na/K ratio which rises during short-period pilocarpine stimulation, due to loss of K and gain of Na. This increased Na/K ratio is not maintained in these glands during prolonged stimulation but is present during the period of accelerated amylase synthesis. The resting parotid gland has a high Na/K ratio which is reduced during stimulation, due to loss of Na, approximately to the level observed for active submaxillary and sublingual glands. This ratio is maintained during prolonged stimulation of parotid gland. The pancreas presents certain differences from the parotid gland in electrolyte levels, but the patterns of change with stimulation agree generally.

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