Glutathione S-Transferase Activity in Rat Pancreas23
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 72 (1) , 121-123
- https://doi.org/10.1093/jnci/72.1.121
Abstract
The biotransformation capability of pancreatic tissue was studied. Michaelis-Menten kinetics were determined for glutathione S-transferase in pancreatic tissue supernatants from control, phenobarbital (PB), and 3-methylcholanthrene (3MCA)-pretreated Sprague-Dawley male rats. The enzyme activity was measured spectrophotometrically with use of 1-chloro-2,4-dinitrobenzene as substrate. Pancreatic activity was about half the hepatic activity, and, further, the activity was not affected by pretreatment with PB or 3MCA as was the liver.Keywords
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