Synthesis and Cytotoxicity of Bidesmosidic Betulin and Betulinic Acid Saponins
- 30 December 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 72 (1) , 72-81
- https://doi.org/10.1021/np800579x
Abstract
The naturally occurring cytotoxic saponin 28-O-beta-D-glucopyranosylbetulinic acid 3 beta-O-alpha-L-arabinopyranoside (3) was easily synthesized along with seven bidesmosidic saponins starting from the lupane-type triterpenoids betulin (1) and betulinic acid (2). As highlighted by the preliminary cytotoxicity evaluation against A549, DLD-1, MCF7, and PC-3 human cancer cell lines, the bidesmosidic betulin saponin 22a, bearing alpha-L-rhamnopyranoside moieties at both C-3 and C-28 positions, was determined to be a potent cytotoxic agent (IC50 1.8-1.9 mu M).This publication has 48 references indexed in Scilit:
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