Release of Inflammatory Mediators from Stimulated Neutrophils

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Abstract
NEUTROPHILS of peripheral blood form the first line of defense against foreign substances introduced into the body by routes other than the digestive tract. As Metchnikoff observed in 1905, encounters between these professional phagocytes and foreign material invariably provoke inflammation:The mechanism by which the organism modifies these substances...is not as yet sufficiently known...But we know, very definitely, that each injection of serum, white of egg, milk, or fatty matter, is followed by a rather considerable aseptic inflammation at the point at which these substances are introduced. The organism digests the substances outside the gastrointestinal canal by means of an . . .

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