Scorpion venoms: taking the sting out of lung disease.
- 1 May 1996
- Vol. 51 (5) , 546-548
- https://doi.org/10.1136/thx.51.5.546
Abstract
Scorpion venoms contain specific toxins which block large conductance calcium-activated potassium (BKCa) channels. Use of these toxins has shown that a significant proportion of the action of bronchodilators such as beta-agonists, theophylline, and nitric oxide occurs as a result of the opening of BKCa channels. Similarly, these toxins have shown that inhibitors of airway neurotransmission also operate via BKCa channels. Drugs that open BKCa channels may be alternative bronchodilators (possibly "airway selective" and with fewer side effects) as well as inhibitors of pathophysiological neurogenic influences in asthma, chronic coughing and sneezing, and chronic bronchitis.Keywords
This publication has 11 references indexed in Scilit:
- A comparison of the effects of SCA40, NS 004 and NS 1619 on large conductance Ca2+‐activated K+ channels in bovine tracheal smooth muscle cells in cultureBritish Journal of Pharmacology, 1995
- β-Adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogmaTrends in Pharmacological Sciences, 1994
- Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms.Journal of Clinical Investigation, 1994
- A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.Thorax, 1993
- Role of K+ channels in the modulation of cholinergic neural responses in guinea‐pig and human airways.The Journal of Physiology, 1992
- Role of Potassium Channels in Bronchodilator Responses in Human AirwaysAmerican Review of Respiratory Disease, 1992
- Calcium-activated potassium channels mediate prejunctional inhibition of peripheral sensory nerves.Proceedings of the National Academy of Sciences, 1992
- Use of toxins to study potassium channelsJournal of Bioenergetics and Biomembranes, 1991
- Muscarinic receptors in airways: recent developmentsJournal of Applied Physiology, 1990
- ASTHMA AS AN AXON REFLEXThe Lancet, 1986