Effects of ciglitazone on insulin resistance and thermogenic responsiveness to acute cold in brown adipose tissue of genetically obese (ob/ob) mice
- 20 January 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 195 (1-2) , 12-16
- https://doi.org/10.1016/0014-5793(86)80120-x
Abstract
Genetically obese (ob/ob) mice develop a marked insulin resistance in brown adipose tissue soon after weaning, and this is paralleled by a fall in the acute activation of the mitochondrial proton conductance pathway in the tissue on cold exposure. Treatment of ob/ob mice with ciglitazone, a new oral hypoglycaemic, led to a restoration of insulin sensitivity in brown adipose tissue. The amelioration of insulin resistance was accompanied by a normalization of the acute, cold‐induced increase in mitochondrial GDP binding. These results support the hypothesis that the development of insulin resistance in brown adipose tissue is an important factor in the impaired thermogenic responsiveness of obese mice.Keywords
This publication has 24 references indexed in Scilit:
- The development of obesity in animals: The role of genetic susceptibilityClinics in Endocrinology and Metabolism, 1984
- The development of insulin resistance in brown adipose tissue may impair the acute cold-induced activation of thermogenesis in genetically obese (ob/ob) miceBioscience Reports, 1984
- Ciglitazone, a new hypoglycaemic agent. 3. effect on glucose disposal and gluconeogenesis in vivo in C57BL/6J-Ob/Ob and ? +/? MiceDiabetologia, 1983
- A new potentiator of insulin actionFEBS Letters, 1983
- Ciglitazone, a New Hypoglycemic Agent: II. Effect on Glucose and Lipid Metabolisms and Insulin Binding in the Adipose Tissue of C57BL/6J-ob/ob and − + / ? MiceDiabetes, 1983
- Ciglitazone, a New Hypoglycemic Agent: I. Studies in ob/ob and db/db Mice, Diabetic Chinese Hamsters, and Normal and Streptozotocin-Diabetic RatsDiabetes, 1983
- Reduction of Insulin Resistance in Obese and/or Diabetic Animals by 5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione (ADD-3878, U-63,287, Ciglitazone), a New Antidiabetic AgentDiabetes, 1983
- The regulation of fatty acid synthesis in brown adipose tissue by insulinProgress in Lipid Research, 1982
- Studies on the activity of brown adipose tissue in suckling, pre-obese, obob miceBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1982
- A mitochondrial defect in brown adipose tissue of the obese (obob) mouse: Reduced binding of purine nucleotides and a failure to respond to cold by an increase in bindingBiochemical and Biophysical Research Communications, 1978