Experimental Production of Blood Disorders in Rat by Injection of Antierythroblastic, Antileukoblastic and Antimegakaryocytic Sera

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Abstract
Rat bone marrow cells were separated into 3 fractions: erythroblasts, leukoblasts, megakaryocytes. By injns. of these fractions into rabbits, sera have been prepared which in vitro produce a deviation of complement in the presence of marrow cells, and in vivo produce specific alterations of the hemopoietic tissues and of the peripheral blood. With antierythroblastic serum erythroblastic hypoplasia in the bone marrow in association with increased peripheral erythrolysis takes place; no alteration of the granulocytic system was observed. With antileukoblastic serum a granulocytic hypoplasia in the bone marrow and peripheral agranulocytosis associated with a moderate hemolytic anemia have been produced. After injn. of antimegakaryocytic serum, peripheral granulocytopenia and granulocytic bone marrow hypoplasia were observed similar to the effect of antileukoblastic immune serum. The causes are discussed.

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