An In Vivo Crossmatching ProceDure for Selected Problem Cases in Blood Banking

Publisher Website
Google Scholar
Abstract
An in vivo crossmatch can be accomplished by measuring the change in the recipient's serum bilirubin after transfusion of 50 ml. of blood from a particular donor unit. A rise of less than 0.5 mg. per 100 ml. has in our experience been good evidence for compatibility. This proceDure was useful in those cases where auto‐antibodies preclude in vitro compatibility testing, also for patients demonstrating irregular hemolytic reactions following transfusion but in whom no responsible antibody can be found. Over a hundred transfusions compatible by the in vivo method have been administered to such problem cases and with uniformly good results as judged by absence of clinical reactions and by increase in hematocrit.