Plant Anticancer Agents, XLVI. Cytotoxic Casbane-Type Constituents of Agrostistachys hookeri
- 1 January 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 51 (1) , 110-116
- https://doi.org/10.1021/np50055a016
Abstract
In addition to the previously characterized agrostistachin [1], three additional cytotoxic macrocyclic casbane-type diterpenes were isolated from a CHCl3 extract of Agrostistachys hookeri, by bioactivity-guided fractionation using the P-388 lymphocytic leukemia cell culture system. These novel compounds, 14-dehydroagrostistachin [2], 17-hydroxyagrostistachin [3], and agroskerin [4], were identified by spectral data comparison to agrostistachin and demonstrated ED50 values of 2.8, 0.8, and 1.4 .mu.g/ml, respectively, with cultured P-388 cells.This publication has 2 references indexed in Scilit:
- Potential Anticancer Agents XXXI. N-Demethylation of FagaronineJournal of Natural Products, 1984
- The structure of crotonitenone, a novel casbane diterpene from Croton nitens Sw. (Euphorbiaceae)Journal of the Chemical Society, Perkin Transactions 1, 1981