Molecular Evolution of Human Influenza A/H3N2 Virus in Asia and Europe from 2001 to 2003
Open Access
- 1 December 2005
- journal article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 43 (12) , 6130-6132
- https://doi.org/10.1128/jcm.43.12.6130-6132.2005
Abstract
Hemagglutinin sequences of 146 human influenza A/H3N2 strains identified in respiratory specimens from Asia and Europe during the 2001-2003 influenza seasons were analyzed by DNA sequencing. Our results suggest that four amino acid substitutions, L25I, H75Q, H155T, and Q156H, led to the antigenic conversion of the previously predominant A/Panama/2007/99-like strains to the more recent A/Fujian/411/2002-like strains.Keywords
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